CDKN1A Antibody

Catalog Number:

31014

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q13485
Gene ID:

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to a region derived from 6-149 amino acids of Human Cyclin-dependent kinase inhibitor 1

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total CDKN1A protein.

Applications:

ELISA WB IHC

Background:

This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene.

References:

appl_detail:

Predicted MW: 18kd
ELISA: 1:500-1:5000
Western blotting: 1:500-1:1000
Immunohistochemistry: 1:25-1:100

Datasheet PDF