Product Datasheet  
CDKN1A Antibody  
Catalog Number: 31014  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:Q13485
    Gene ID:
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Fusion protein corresponding to a region derived from 6-149 amino acids of Human Cyclin-dependent kinase inhibitor 1
  • reactivity：  
  • Hu
  • appl_detail：  

  • Predicted MW: 18kd
    ELISA: 1:500-1:5000
    Western blotting: 1:500-1:1000
    Immunohistochemistry: 1:25-1:100

  • other_names：  
  • Cyclin-dependent kinase inhibitor 1, P21, CIP1, SDI1, WAF1, CAP20, CDKN1, MDA-6, p21CIP1
  • Purification：  
  • Specificity：  
  • The antibody detects endogenous level of total CDKN1A protein.
  • Applications：  
  • ELISA WB IHC
  • Background：  

  • This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene.




 
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