HORMAD2 antibody

Catalog Number:

31898

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9BQL6
NCBI Protein#: BC030013

Form of Antibody:

pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Storage/Stability:

Immunogen:

Fusion protein of human HORMAD2

Purification:

Antigen affinity purification

Specificity/Sensitivity:

Applications:

IHC

Background:

Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation (By similarity).

References:

appl_detail:

IHC dilution:1:50-1:100

Datasheet PDF