Product Datasheet  
HORMAD2 antibody  
Catalog Number: 31898  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: Q9BQL6
    NCBI Protein#: BC030013
  • Form of Antibody：  
  • pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Fusion protein of human HORMAD2
  • reactivity：  
  • Hu
  • appl_detail：  

  • IHC dilution:1:50-1:100
  • other_names：  
  • CT46.2
  • Purification：  
  • Antigen affinity purification
  • Specificity：  
  • Applications：  
  • IHC
  • Background：  
  • Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation (By similarity).



 
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