Acetyl-DNMT1-K1127/K1129/K1131/K1133 pAb

Catalog Number:

30656

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:P26358
NCBI Gene ID:1786

Form of Antibody:

Avoid freeze / thaw cycles.|Buffer: PBS with 50% glycerol, pH7.4.

Storage/Stability:

Immunogen:

A synthetic peptide of human DNMT1

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

IHC,IF

Background:

This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants.

References:

appl_detail:

IHC 1:50 - 1:100
IF 1:50 - 1:100

Datasheet PDF