Product Datasheet
ATP6V1E1 Polyclonal Antibody
Catalog Number: 30481
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot#:P36543
NCBI Gene ID:529
- Form of Antibody:
- Avoid freeze / thaw cycles.|Buffer: PBS with 50% glycerol, pH7.4.
- Immunogen:
- Recombinant fusion protein of human ATP6V1E1 (NP_001687.1).
- reactivity:
- Human,Mouse,Rat
- appl_detail:
- WB 1:1000 - 1:2000
IHC 1:50 - 1:200
- other_names:
- ATP6V1E1; ATP6E; ATP6E2; ATP6V1E; P31; Vma4; ARCL2C; V-type proton ATPase subunit E 1
- Purification:
- Affinity purification
- Background:
- This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain E subunit isoforms. Pseudogenes for this gene have been found in the genome.
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