Product Datasheet
ASIC2 Polyclonal Antibody
Catalog Number: 27460
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot#:Q16515
NCBI Gene ID:40
- Form of Antibody:
- Avoid freeze / thaw cycles.|Buffer: PBS with 50% glycerol, pH7.4.
- Immunogen:
- Recombinant fusion protein of human ASIC2 (NP_001085.2).
- reactivity:
- Human,Mouse,Rat
- appl_detail:
- WB 1:1000 - 1:2000
- other_names:
- ASIC2; ACCN; ACCN1; ASIC2a; BNC1; BNaC1; MDEG; hBNaC1; acid-sensing ion channel 2
- Purification:
- Affinity purification
- Background:
- This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified.
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