Product Datasheet
KPNA5 Antibody
Catalog Number: 25411
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot:O15131
Gene ID:3841
- Form of Antibody:
- Supplied in PBS containing 0.02% sodium azide.
- Storage:
- Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Immunogen:
- Raised against an 18 amino acid peptide near the amino terminus of human KPNA5.
- other_names:
- Karyopherin alpha nucleoprotein interactor 5, Importin alpha 6, IPOA6, SRP6
- Purification:
- Affinity chromatography purified via peptide column
- Specificity:
- KPNA5 antibody is predicted to not cross-react with other Importin alpha family members.
- Background:
- Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA5 belongs to a subfamily within the KPNA family that also includes KPNA4 and 6 and is thought to be involved in NLS-dependent protein imort into the nucleus.
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