Product Datasheet  
LASS5 Antibody  
Catalog Number: 24719  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:Q8N5B7
    Gene ID:91012
  • Form of Antibody：  
  • Supplied in PBS containing 0.02% sodium azide.
  • Storage：  
  • Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Immunogen：  
  • Raised against a 18 amino acid peptide near the amino terminus of the human LASS5.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • other_names：  
  • Longevity Assurance Homolog 5, LAG1, TRH4
  • Purification：  
  • Affinity chromatography purified via peptide column
  • Specificity：  
  • Multiple isoforms of LASS5 are known to exist. This antibody may cross-react with the highly homologous LASS6.
  • Applications：  
  • ELISA WB IHC
  • Background：  
  • The LASS (longevity assurance homolog) family members represent a subgroup of the homeobox gene family and are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1-6) and all are involved in ceramide synthesis during cell growth regulation and cancer differentiation. LASS5, also called Trh4, is a 392 amino acid endoplasmic reticulum, multi-pass membrane protein. Functioning as a dihydro-ceramide synthase, LASS5 is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked palmitoyl-ceramide) in a fumonisin B1-independent manner. It uses palmitoyl-CoA as an acyl donor and is involved in the synthesis of C14, C16 and C18-ceramide. LASS5 is the most abundantly expressed and predominant ceramide synthase isoform in lung epithelia. Recent studies show that LASS5 partially correct growth and apoptosis.



 
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