Product Datasheet  
Slc35D1 Antibody  
Catalog Number: 24703  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:Q9NTN3
    Gene ID:23169
  • Form of Antibody：  
  • Supplied in PBS containing 0.02% sodium azide.
  • Storage：  
  • Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Immunogen：  
  • Raised against a 14 amino acid peptide near the amino terminus of the human Slc35D1.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • other_names：  
  • Solute carrier family 35 member D1, UDP-glucuronic acid, UDP-N-acetylgalactosamine transporter
  • Purification：  
  • Affinity chromatography purified via peptide column
  • Specificity：  
  • This antibody is predicted to not cross-react with the highly homologous Slc35D2.
  • Applications：  
  • ELISA WB
  • Background：  
  • The solute carrier family Slc35 consists of at least 17 proteins that act as nucleotide sugar transporters localized to the Golgi apparatus and endoplasmic reticulum. The role of the ER-resident Slc family member Slc35D1 is to transport both UDP-glucuronic acid and UDP-N-acetylgalactosamine. These molecules can serve as substrates for chondroitin sulfate biosynthesis and mice lacking the Slc35D1 gene developed a lethal form of skeletal dysplasia with severe shortening of limbs and facial structures. Examination of epiphyseal cartilage in these mice revealed a decreased proliferating zone with round chrondrocytes, scarce matrices, and reduced proteoglycan aggregates. Loss of function mutations in human Slc35D1 cause Schneckenbecken dysplasia, a severe skeletal dysplasia.



 
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