Product Datasheet  
EVER1 Antibody  
Catalog Number: 24662  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:Q7Z403
    Gene ID:11322
  • Form of Antibody：  
  • Supplied in PBS containing 0.02% sodium azide.
  • Storage：  
  • Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Immunogen：  
  • Raised against a 14 amino acid peptide from near the amino terminus of human EVER1.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • other_names：  
  • EV1, EVIN1, Transmembrane protein channel-like protein 6, TMC6
  • Purification：  
  • Affinity chromatography purified via peptide column
  • Specificity：  
  • At least four isoforms of EVER1 are known to exist. This EVER1 antibody does not cross-react with EVER2.
  • Applications：  
  • ELISA WB IHC
  • Background：  
  • Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes, EVER1 and EVER2, located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. Both EVER1 and EVER2 are members of the transmembrane channel-like (TMC) protein family. EVER1 possesses eight trans-membrane domains and two leucine zipper motifs. EVER1 and EVER2 form a complex and interact with the zinc transporter 1 (ZnT-1), suggesting that EVER1 and EVER2 act to regulate cellular zinc balance.



 
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