Product Datasheet  
Unc93b Antibody  
Catalog Number: 24665  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:Q9H1C4
    Gene ID:81622
  • Form of Antibody：  
  • Supplied in PBS containing 0.02% sodium azide.
  • Storage：  
  • Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Immunogen：  
  • Raised against a 19 amino acid peptide from near the amino terminus of human Unc93b.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • other_names：  
  • Unc93b1, homolog of C. elegans Unc93
  • Purification：  
  • Affinity chromatography purified via peptide column
  • Specificity：  
  • Multiple isoforms of Unc93a are known to exist. This antibody will not cross-react with Unc93a.
  • Applications：  
  • ELISA WB IHC
  • Background：  
  • The endoplasmic reticulum (ER) protein Unc93b, a human homolog of the C. elegans Unc93 gene, was initially identified by a forward genetic screen using N-ethyl-N-nitrosourea where a histidine-to-arginine substitution in Unc93b caused defects in Toll-like receptor (TLR) 3, 7 and 9 signaling. Unlike Unc93a, another homolog of the C. elegans Unc93 gene whose function is unknown, Unc93b specifically interacts with TLR3, 7 and 9; the histidine-to-arginine point mutation used to identify Unc93b abolishes this interaction. Mice carrying this point mutation are highly susceptible to infection with a number of viruses, indicating that Unc93b plays an important role in innate immunity.



 
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