Product Datasheet  
SIRP alpha Antibody  
Catalog Number: 24015  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:P78324
    Gene ID:140885
  • Form of Antibody：  
  • Supplied in PBS containing 0.02% sodium azide.
  • Storage：  
  • Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Immunogen：  
  • Raised against a peptide corresponding to amino acids near the carboxy terminus of human SIRP alpha 1. The sequences of the immunogenic peptide differ from those of mouse, rat and bovine by one amino acid.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Predicted MW: 75 - 110 kd
  • other_names：  
  • SHPS-1, SIRPa
  • Purification：  
  • DEAE purified
  • Specificity：  
  • Recognizes SIRP alpha 1, 2 and 3.
  • Applications：  
  • ELISA WB ICC
  • Background：  
  • Protein tyrosine phosphatases (PTPases) SHP-1 and SHP-2 are critical regulators in the intracellular signaling pathways that result in cell responses such as mitosis, differentiation, migration, survival, transformation or death. SHP-2 is a signal transducer for several receptor tyrosine kinases and cytokine receptors. A novel SHP-2 associated glycoprotein was recently cloned from human, rat, mouse and cattle by several labs and was designated SIRPalpha, SHPS-1, MyD-1, BIT and p84. SIRPalpha is a new gene family containing at least fifteen members. SIRPalpha is a substrate of many activated tyrosine kinases such as insulin receptor, EGFR, PDGFR and src, and a specific docking protein for SHP-2. SIRPalpha has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones and cell adhesion and plays a general role in different physiological and pathological processes.



 
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