Product Datasheet
NKG2-A(CD159a) antibody
Catalog Number: 22434
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot:P26715
Gene ID:3821
- Form of Antibody:
- Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
- Storage:
- Store at -20˚C for long term preservation (recommended). Store at 4˚C for short term use.
- Immunogen:
- Synthetic peptide contain a sequence corresponding to a region within amino acids 1 and 15 of NKG2-A (CD159a)
- appl_detail:
- Predicted MW: 26kd
Western blotting: 1:500-1:3000
Immunofluorescence: 1:100-1:200
- other_names:
- CD159A; MGC13374; MGC59791; NKG2; NKG2A
- Purification:
- Purified by antigen-affinity chromatography.
- Background:
- Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. [provided by RefSeq]
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