Product Datasheet  
HLA-DMA antibody  
Catalog Number: 22427  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • NCBI Gene ID: 3108
    NCBI mRNA#: BC011447
    NCBI Protein#: AAH11447
  • Form of Antibody：  
  • Supplied in 0.1M Tris-buffered saline with 20% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
  • Storage：  
  • Store at -20˚C for long term preservation (recommended). Store at 4˚C for short term use.
  • Immunogen：  
  • Recombinant protein fragment contain a sequence corresponding to a region within amino acids 52 and 255 of HLA-DMA
  • reactivity：  
  • Hu
  • appl_detail：  
  • Predicted MW: 29kd
    Western blotting: 1:500-1:3000
    Immunohistochemistry: 1:100-1:250
  • other_names：  
  • Purification：  
  • Purified by antigen-affinity chromatography.
  • Specificity：  
  • Applications：  
  • WB IHC
  • Background：  
  • HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. [provided by RefSeq]



 
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