Product Datasheet  
ERAB Antibody  
Catalog Number: 21602  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q99714
    NCBI Protein: NP_004484.1
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around aa.253~257(L-D-G-A-I)derived from Human ERAB.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Predicted MW: 27kd
    Western blotting: 1:500~1:1000
  • other_names：  
  • ABAD; CAMR; HCD2; MHBD; HADH2
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Specificity：  
  • The antibody detects endogenous level of total ERAB protein.
  • Applications：  
  • WB
  • Background：  
  • Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD).

    Holzmann J., Frank P., Loeffler E., Bennett K.L., Gerner C., Rossmanith W. Cell 135:462-474(2008)



 
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