Product Datasheet  
CK2a Antibody  
Catalog Number: 21572  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P68400
    NCBI Protein: NP_001886.1
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around aa. 353~357 (S-G-I-S-S) derived from Human CK2α.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  

  • Predicted MW: 42kd
    Western blotting: 1:1000

  • other_names：  
  • CKII; CK2A1; CSNK2A1
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Specificity：  
  • The antibody detects endogenous levels of total CK2 protein.
  • Applications：  
  • WB
  • Background：  

  • Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The a and a' chains contain the catalytic site. Participates in Wnt signaling. CK2 phosphorylates 'Ser-392' of p53/TP53 following UV irradiation.

    Keller D.M., Zeng X., et al., Mol. Cell 7:283-292(2001)
    Keller D.M., Lu H. et al., J. Biol. Chem. 277:50206-50213(2002)
    Trembley J.H., Tatsumi S., et al., Mol. Cell. Biol. 25:1446-1457(2005)
    Niefind K., Guerra B., et al., Acta Crystallogr. D 56:1680-1684(2000)




 
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