Product Datasheet  
PPARg Antibody  
Catalog Number: 21649  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P37231
    NCBI Protein: NP_005028.4
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around aa.50~54 (L-S-V-M-E) derived from Human PPARg
  • reactivity：  
  • Hu Ms
  • appl_detail：  
  • Predicted MW: 53 57kd
    Western blotting: 1:500~1:1000
  • other_names：  
  • GLM1; NR1C3; PPARG1; PPARG2; PPARG
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Specificity：  
  • The antibody detects endogenous levels of total PPARg protein.
  • Applications：  
  • WB
  • Background：  
  • Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. "Identification, characterization, and tissue distribution of human peroxisome proliferator-activated receptor (PPAR) isoforms PPARgamma2 versus PPARgamma1 and activation with retinoid X receptor agonists and antagonists."

    Mukherjee R., Jow L., Croston G.E., et al. J. Biol. Chem. 272:8071-8076(1997) "Cloning and characterization of RAP250, a nuclear receptor coactivator."
    Caira F., Antonson P., Pelto-Huikko M., et al. J. Biol. Chem. 275:5308-5317(2000) "Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor a."
    Qi C., Chang J., Zhu Y.,et al. J. Biol. Chem. 277:28624-28630(2002)



 
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