Product Datasheet  
ABL1/2 (Ab-393/439) Antibody  
Catalog Number: 21530  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:P00519
    Gene ID:25
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around aa.391~395/437~441(D-T-Y-T-A) derived from Human ABL1/2.
  • reactivity：  
  • Hu Ms
  • appl_detail：  

  • Predicted MW: 135 210kd
    Western blotting: 1:500~1:1000

  • other_names：  
  • ABL; v-abl; c-ABL; p150; JTK7
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Specificity：  
  • The antibody detects endogenous levels of total ABL1/2 protein.
  • Applications：  
  • WB
  • Background：  

  • Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.

    Wang, J.Y. et al. (2000) Oncogene 19, 5643-5650.
    Danial, N.N. et al. (2000) Oncogene 19, 2523-2531.
    Brasher, B.B. et al. (2000) J. Biol. Chem. 275, 35631-35637.
    Pluk, H. et al. (2002) Cell 108, 247-259.




 
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