Product Datasheet  
PI3 Kinase p85/p55(Ab-467/199) Antibody  
Catalog Number: 21508  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:P27986
    Gene ID:5295
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around aa.465~469(L-Y-E-E-Y) derived from Human PI3 Kinase p85/p55.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  

  • Predicted MW: 55, 85kd
    Immunohistochemistry: 1:50~1:100

  • other_names：  
  • p85, AGM7, p85-ALPHA, p55, p55-GAMMA
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Specificity：  
  • The antibody detects endogenous level of total PI3 Kinase p85/p55 protein.
  • Applications：  
  • IHC
  • Background：  

  • PI3K binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.

    Stoyanov, B. et al. (1995) Science 269, 690-3.
    Simpson, L. and Parsons, R. (2001) Exp Cell Res 264, 29-41.
    Neri, L.M. et al. (2002) Biochim Biophys Acta 1584, 73-80.




 
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