Product Datasheet  
REST Antibody  
Catalog Number: 21475  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q13127
    NCBI Protein: NP_001180437.1
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around aa.873~877(R-E-E-A-S) derived from Human REST.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Predicted MW: 121kd
    Western blotting: 1:500~1:1000
  • other_names：  
  • NRSF; XBR; REST
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Specificity：  
  • The antibody detects endogenous level of total REST protein.
  • Applications：  
  • WB
  • Background：  
  • Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.

    Chong J.A.et.al. (1995)Cell 80:949-957
    Schoenherr C.J.et.al.(1995)Science 267:1360-1363
    Scholl T.et.al.(1996)J. Immunol. 156:1448-1457
    Lunyak V.V.et.al. (2002)Science 298:1747-1752



 
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