Product Datasheet  
synaptophysin 2 Antibody  
Catalog Number: 21452  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P22831
    NCBI Protein: NP_076464.1
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around aa.257~261(G-P-T-S-F)derived from Rat synaptophysin 2.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  

  • Predicted MW: 37kd
    Western blotting: 1:500~1:1000

  • other_names：  
  • Synpr
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Specificity：  
  • The antibody detects endogenous levels of total synaptophysin 2 protein.
  • Applications：  
  • WB
  • Background：  

  • Synaptophysin (SYP) is a neuronal synaptic vesicle glycoprotein that is expressed in neuroendocrine cells and neoplasms, and thus can be used as a marker in tumor diagnosis (1). Synaptophysin contains four transmembrane domains that form a hexameric channel or gap junction-like pore (2). Synaptophysin binds to the SNARE protein synaptobrevin/VAMP, which prevents the inclusion of synaptobrevin in the synaptic vesicle fusion complex and creates a pool of synaptobrevin for exocytosis when synapse activity increases (3). Synaptophysin is also responsible for targeting synaptobrevin 2/VAMP2 to synaptic vesicles, a critical component of the fusion complex (4).

    Wiedenmann, B. et al. (1986) Proc Natl Acad Sci USA 83, 3500-4.
    Valtorta, F. et al. (2004) Bioessays 26, 445-53.
    Arthur, C.P. and Stowell, M.H. (2007) Structure 15, 707-14.
    Bonanomi, D. et al. (2007) Biochem J 404, 525-34.




 
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