Product Datasheet  
ASPSCR1 Antibody  
Catalog Number: 21430  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q9BZE9
    NCBI Protein: NP_076988.1
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around aa.303 ~307(P-Q-Q-E-Q) derived from Human ASPSCR1.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Predicted MW: 70-75kd
    Western blotting: 1:500~1:1000
  • other_names：  
  • ASPL; RCC17; TUG; UBXD9; UBXN9
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Specificity：  
  • The antibody detects endogenous levels of total ASPSCR1 protein.
  • Applications：  
  • WB
  • Background：  
  • Tug (Tether containing UBX domain for GLUT4), also known as ASPL, ASPSCR1, RCC17, UBXD9, UBXN9, was first identified as a chromosomal translocation partner for TFE3 in patients with Alveolar soft part sarcoma and contains an UBX-like domain in its C-terminal region. Tug is found to tether GLUT4 in intracellular vesicles and to release GLUT4 for cell surface translocation upon insulin stimulation . Stable Tug depletion or expression of a dominant negative form stimulates GLUT4 redistribution.

    Ladanyi, M. et al. (2001) Oncogene 20, 48-57.
    Bogan, J.S. et al. (2003) Nature 425, 727-33.
    Yu, C. et al. (2007) J Biol Chem 282, 7710-22.



 
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