Product Datasheet  
Caspase 9 Antibody  
Catalog Number: 21422  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P55211
    NCBI Protein: NP_001220.2
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around aa.301~305 (T-S-P-E-D) derived from Caspase 9
  • reactivity：  
  • Hu
  • appl_detail：  
  • Predicted MW: 47 37 35kd
    Western blotting: 1:1000
  • other_names：  
  • ICE-like apoptotic protease 6
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Specificity：  
  • The antibody detects endogenous level of total Caspase 9 protein.
  • Applications：  
  • WB
  • Background：  
  • Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.

    Zou, H. et al. (1999) J. Biol. Chem. 274, 11549-11556.
    Deveraux, Q. L. et al. (1998) EMBO J. 17, 2215-2223.
    Li, P. et al. (1997) Cell 91, 479-489.



 
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