Product Datasheet  
Caspase 3 Antibody  
Catalog Number: 21420  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P42574
    NCBI Protein: NP_004337.2
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around aa.29~33 (S-G-I-S-L) derived from Caspase 3.
  • reactivity：  
  • Hu
  • appl_detail：  

  • Predicted MW: 35 17kd
    Western blotting: 1:1000

  • other_names：  
  • Apopain
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Specificity：  
  • The antibody detects endogenous level of total Caspase 3 protein.
  • Applications：  
  • WB
  • Background：  

  • Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.

    Gervais, F. G et al.Cell 97: 395-406, 1999.
    Nicholson, D. W. et al. (1995) Nature 376, 37-43.




 
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