Product Datasheet  
CRY1 Antibody  
Catalog Number: 21414  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q16526
    NCBI Protein: NP_031797.1
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around aa.551~555 (S-Q-G-S-G) derived from Human CRY1.
  • reactivity：  
  • Ms
  • appl_detail：  

  • Predicted MW: 60kd
    Western blotting: 1:500~1:1000

  • other_names：  
  • PHLL1
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Specificity：  
  • The antibody detects endogenous level of total CRY1 protein.
  • Applications：  
  • WB
  • Background：  

  • Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL

    Morioka N,et al. (2010) J Pharmacol Sci.113(3):234-45.
    Fonseca F,et al. (2010) Mol Diagn Ther.14(3):171-8.
    Stratmann M,et al.(2010) Genes Dev.24(12):1317-28.




 
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