Product Datasheet  
Melanoma-associated antigen D1 Antibody  
Catalog Number: 21408  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q9QYH6
    NCBI Protein: NP_062765.1
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide with sequence C-EAEARAEARNRMGIGDE derived from Mouse Melanoma-associated antigen D1.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  

  • Predicted MW: 95kd
    Western blotting: 1:500~1:1000

  • other_names：  
  • MAGED1
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Specificity：  
  • The antibody detects endogenous level of total Melanoma-associated antigen D1 protein.
  • Applications：  
  • WB
  • Background：  

  • Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Binds p75NTR and antagonizes its association with TrkA, inhibits cell cycle progression, and facilitates p75NTR-mediated apoptosis. May act as a regulator of the function of DLX family members. May regulate p53 transcriptional activity and inhibit cell proliferation. Enhances p53 phosphorylation and accumulation.

    Zhao Z,et al.(2002) Sci China C Life Sci.45(4):412-20.
    Shen WG,et al.(2007) Cell Commun Adhes.14(1):21-31.
    Cheresh DA,et al. (1984) J Biol Chem.259(12):7453-9.




 
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