Product Datasheet  
PKCz(Ab-410) Antibody  
Catalog Number: 21314  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q05513
    NCBI Protein: NP_002735.3
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around aa. 408~412 ( T-S-T-F-C) derived from PKCz
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Predicted MW: 78kd
    Western blotting: 1:500~1:1000
    Immunohistochemistry: 1:50~1:100
  • other_names：  
  • PKC2; PKC-ZETA; PRKCZ
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Specificity：  
  • The antibody detects endogenous levels of total PKCz protein.
  • Applications：  
  • WB IHC
  • Background：  
  • This is a calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. Subunit of a quaternary complex that plays a central role in epithelial cell polarization.

    Parmentier JH, et al. (2004) BMC Cell Biol; 5: 4.
    Castrillo A, et al. (2003) Mol Cell Biol; 23(4): 1196-1208.
    Paramio JM, et al. ( 2001) Mol Cell Biol; 21(21): 7449-7459.
    Braiman L, et al. (2001) Mol Cell Biol; 21(22): 7852-7861.



 
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