Product Datasheet  
Keratin 18(Ab-33) Antibody  
Catalog Number: 21306  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P05783
    NCBI Protein: NP_000215.1
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around aa.31~35 (A-A-S-V-Y) derived from Human Keratin 18 (CK18).
  • reactivity：  
  • Hu
  • appl_detail：  
  • Predicted MW: 46kd
    Western blotting: 1:500~1:1000
    Immunohistochemistry: 1:50~1:100
  • other_names：  
  • CK 18; CK18; CYK18; Cytokeratin endo B; K18
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Specificity：  
  • The antibody detects endogenous level of total Keratin 18 protein.
  • Applications：  
  • WB IHC
  • Background：  
  • KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. utations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.

    Ramaekers, F.C. and Bosman, F.T. (2004) J. Pathol. 204, 351-354.
    Chang, L. and Goldman, R.D. (2004) Nat. Rev. Mol. Cell Biol. 5, 601-613.
    Moll, R. et al. (1982) Cell 31, 11-24.



 
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