Product Datasheet  
IKK-b(Ab-199) Antibody  
Catalog Number: 21305  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: O14920
    NCBI Protein: NP_001547.1
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around aa.197~201 (Q-K-Y-T-V) derived from Human IKK-b.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Predicted MW: 87kd
    Western blotting: 1:500~1:1000
    Immunofluorescence: 1:100~1:200
  • other_names：  
  • I-kappa-B kinase 2; I-kappa-B-kinase beta; IKK2; IkBKB; NFKBIKB
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Specificity：  
  • The antibody detects endogenous level of total IKK-bprotein.
  • Applications：  
  • WB IF
  • Background：  
  • Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also phosphorylates NCOA3.

    Chen RA, et al. PLoS Pathog. 2008 Feb 8;4(2):e22
    Yen CJ,et al. Cancer Res. 2008 Apr 15;68(8):2632-40



 
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