Product Datasheet  
c-Cbl(Ab-700) Antibody  
Catalog Number: 21549  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P22681
    NCBI Protein: NP _005179.2
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around aa. 698~702 (T-E-Y-M-T) derived from Human c-Cbl.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Predicted MW: 120kd
    Western blotting: 1:500~1:1000
    Immunohistochemistry: 1:50~1:100
  • other_names：  
  • Signal transduction protein CBL; Proto-oncogene c-CBL; Casitas B-lineage lymphoma proto-oncogene; RING finger protein 55;
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Specificity：  
  • The antibody detects endogenous level of total c-Cbl protein.
  • Applications：  
  • WB IHC
  • Background：  
  • Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling.

    Blake, T.J. et al. (1991) Oncogene 6, 653-657.
    Thien, C.B. and Langdon, W.Y. (1998) Immunol. Cell Biol. 76, 473-482.
    Kamei, T. et al. (2000) Int. J. Oncol. 17, 335-339.
    Hunter, C. et al. (1999) J. Biol. Chem. 274, 2097-2106.



 
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