Product Datasheet  
H2B Antibody  
Catalog Number: 21417  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P33778
    NCBI Protein: NP_003519.1
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around aa.41~45 (Y-V-Y-K-V) derived from Human H2B.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  

  • Predicted MW: 14kd
    Western blotting: 1:500~1:1000

  • other_names：  
  • H2BQ; GL105; H2B.1; H2BFQ; H2BGL105
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Specificity：  
  • The antibody detects endogenous level of total H2B protein.
  • Applications：  
  • WB
  • Background：  

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

    Borchert GM,et al. (2010) PLoS One.5(7):e11641.
    Pennini ME,et al.(2010) PLoS Pathog.6(7):e1000995.
    Lu C,et al. (2010) Sci China Life Sci.53(6):663-8.




 
© Signalway Biotechnology All Rights Reserved.