Product Datasheet  
IGF-1R(Ab-1346) Antibody  
Catalog Number: 21303  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P08069
    NCBI Protein: NP_000866.1
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around aa.1344~1348 (Q-P-Y-A-H) derived from Human IGF-1R .
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Predicted MW: 200 95 kd
    Western blotting: 1:500~1:1000
    Immunohistochemistry: 1:50~1:100
  • other_names：  
  • Insulin-like growth factor I receptor; CD221; IGF1R; kinase IGF1R;
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Specificity：  
  • The antibody detects endogenous level of total IGF-1R protein.
  • Applications：  
  • WB IHC
  • Background：  
  • This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1.

    Adams, T.E. et al. (2000) Cell. Mol. Life Sci. 57, 1050-1093
    Baserga, R. et al. (2000) Oncogene 19, 5574-5581
    Scheidegger, K.J. et al. (2000) J. Biol. Chem. 275, 38921-38928.
    O'Connor R, et al. Mol Cell Biol 1997 Jan; 17(1): 427-35



 
© Signalway Biotechnology All Rights Reserved.