Product Datasheet  
GSK3α/β(Ab-279/216) Antibody  
Catalog Number: 21301  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:P49840
    Gene ID:2931
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around aa.277~281/214~218 (V-S-Y-I-C) derived from Human GSK3α/β.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  

  • Predicted MW: 46, 51kd
    Western blotting: 1:500~1:1000

  • other_names：  
  • Factor A; GSK-3 alpha/beta; kinase GSK3-alpha/beta
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Specificity：  
  • The antibody detects endogenous level of total GSK3α/β protein.
  • Applications：  
  • WB
  • Background：  

  • Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin.

    Chin PC, et al. Brain Res Mol Brain Res 2005 Jun 13; 137(1-2): 193-201
    Takahashi-Yanaga F, et al. Biochem Biophys Res Commun 2004 Apr 02; 316(2): 411-415
    Fan G, et al. J Biol Chem 2003 Dec 26; 278(52): 52432-52436
    Liao X, et al. Mol Cancer Ther 2003 Nov; 2(11): 1215-1222




 
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