Product Datasheet  
Integrin b3(Ab-785) Antibody  
Catalog Number: 21274  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P05106
    NCBI Protein: NP_000203.2
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around aa.783~787 (I-T-Y-R-G) derived from Human Integrin B3/ITGB3.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  

  • Predicted MW: 110kd
    Western blotting: 1:500~1:1000

  • other_names：  
  • CD61 antigen; GP3A; GPIIIa; ITB3; Platelet membrane glycoprotein IIIa
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Specificity：  
  • The antibody detects endogenous level of total Integrin b3 protein.
  • Applications：  
  • WB
  • Background：  

  • The Itg-Beta3 gene encodes the beta subunit of the platelet membrane adhesive protein receptor complex Itg-Beta3 protein, which belongs to the Integrin class of cell adhesion molecule receptors that share a common heterotrimeric structure with a and Beta subunits. It is a common Beta subunit of the platelet complex and of two other Integrins (Fibronectin and Vitronectin Receptors), which have distinct a subunits. Itg-Beta3 has been implicated in a wide variety of functions, including platelet aggregation and thrombosis and implantation, placentation, angiogenesis, bone remodeling, and tumor progression. Glanzmann Thrombasthenia can result from defects in the genes for either the Itg-a2B or the Itg-Beta3 subunit

    Sujoy Bhattacharya, et al. (2006) Biochem J. August 1; 397(Pt 3): 437




 
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