Product Datasheet  
EGFR(Ab-1110) Antibody  
Catalog Number: 21256  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P00533
    NCBI Protein: NP_005219.2
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around aa. 1108~1112 (P-V-Y-H-N) derived from Human EGFR.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Predicted MW: 175kd
    Western blotting: 1:500~1:1000
    Immunohistochemistry: 1:50~1:100
  • other_names：  
  • Receptor tyrosine-protein kinase ErbB-1
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Specificity：  
  • The antibody detects endogenous level of total EGFR protein.
  • Applications：  
  • WB IHC
  • Background：  
  • Receptor for EGF, but also for other members of the EGF family, as TGF-a, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with SRC and CTNNB1/beta-catenin.

    Kaisa Erjala, et al. (2006) Clin. Cancer Res Jul 2006; 12: 4103 - 4111.
    Judit Anido, et al. (2003) Clin. Cancer Res ; 9: 1274.
    Julian Andreev, et al. (2001) J. Biol. Chem ; 276: 20130 - 20135.
    Suil Kim, et al. (2002) Am J Physiol Lung Cell Mol Physiol; 283: 67.



 
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