Product Datasheet
c-Kit(Ab-721) Antibody
Catalog Number: 21232
Technical:tech@swbio.com
Information:info@swbio.com
Description
- Swiss-Prot No.:
- Swiss-Prot: P11362
NCBI Protein: NP_000213.1
- Form of Antibody:
- Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
- Storage:
- Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
- Immunogen:
- Peptide sequence around aa.719~723 (N-E-Y-M-D) derived from Human c-Kit.
- appl_detail:
- Predicted MW: 145kd
Western blotting: 1:500~1:1000
- other_names:
- KIT; CD117; SCFR; PBT;
- Purification:
- Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
- Specificity:
- The antibody detects endogenous level of total c-Kit protein.
- Background:
- This is the receptor for stem cell factor (mast cell growth factor). It has a tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase (Pi3K)
Kimura W,et al.(2007)Hepatogastroenterology.54(80):2203-8.
Naeem M,et al.(2002)Hum Pathol. 33(12):1182-7.
Jankulovski N, et al.(2006)Prilozi. 27(2):59-70.
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