Product Datasheet  
DNA PKcs(Ab-2609) Antibody  
Catalog Number: 21179  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P78527
    NCBI Protein: NP_001075109.1
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around aa.2607~2611 (V-E-T-Q-A) derived from Human DNA-PK.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Predicted MW: 450kd
    Western blotting: 1:500~1:1000
  • other_names：  
  • DNPK1; PRKD; PRKDC; XRCC7; P460
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Specificity：  
  • The antibody detects endogenous level of total DNA PKcs protein.
  • Applications：  
  • WB
  • Background：  
  • The PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku (MIM 152690), which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity; PRKDC must be bound to DNA to express its catalytic properties

    Chan DW, et al. (2002) Genes Dev. Sep 15; 16(18): 2333-2338
    Ding Q, et al. (2003) Mol Cell Biol. Aug; 23(16): 5836-5848
    Douglas P, et al. (2002) Biochem J. Nov 15; 368(Pt 1): 243-251



 
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