Product Datasheet  
ICAM-1(Ab-512) Antibody  
Catalog Number: 21106  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P05362
    NCBI Protein: NP_000192.2
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around aa. 510~514 (K-K-Y-R-L) derived from Human ICAM-1.
  • reactivity：  
  • Hu
  • appl_detail：  

  • Predicted MW: 89 92kd
    Western blotting: 1:500~1:1000
     

  • other_names：  
  • ICA1; ICAM1;
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Specificity：  
  • The antibody detects endogenous level of total ICAM-1 protein.
  • Applications：  
  • WB
  • Background：  

  • ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin a-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.

    Greenwood J, et al. (2003) J Immunol; 171(4):2099-2108.
    Zhou Z, et al. (2005) Eur J Pharmacol; 513(1-2):1-8.
    Chen YH, et al. (2001) J Cell Biochem; 82(3):512-521
     




 
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