Product Datasheet  
IGF-1R(Ab-1161) Antibody  
Catalog Number: 21080  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P08069
    NCBI Protein: NP_000866.1
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around aa.1159~1163 (D-I-Y-E-T) derived from Human IGF-1R .
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Predicted MW: 200 95 kd
    Western blotting: 1:500~1:1000
    Immunohistochemistry: 1:50~1:100
    Immunofluorescence: 1:100~1:200
  • other_names：  
  • Insulin-like growth factor I receptor; CD221; IGF1R; kinase IGF1R;
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Specificity：  
  • The antibody detects endogenous level of total IGF-1R protein.
  • Applications：  
  • WB IHC IF
  • Background：  
  • This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1.

    Li S, et al. (1994) J Biol Chem; 269(51).
    Hernandez-Sanchez C, et al. (1995) J Biol Chem.



 
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