Product Datasheet  
p95/NBS1(Ab-343) Antibody  
Catalog Number: 21058  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: O60934
    NCBI Protein: NP_002476.2
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around aa.341~345 (S-L-S-Q-G) derived from Human p95/NBS1.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Predicted MW: 95kd
    Western blotting: 1:500~1:1000
    Immunohistochemistry: 1:50~1:100
  • other_names：  
  • NBN
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Specificity：  
  • The antibody detects endogenous level of total p95/NBS1 protein.
  • Applications：  
  • WB IHC
  • Background：  
  • Mutations in p95/NBS1 gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.

    Hsu HL, et al (2005)Oncogene; 24(31): 4956-64.
    Falck J, et al. (2005) Nature; 434(7033): 605-11.
    Buscemi G, et al. (2004) Oncogene; 23(46): 7691-700.
    Beausoleil SA, et al. (2004) Proc Natl Acad Sci U S A; 101(33): 12130-5.



 
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