Product Datasheet  
STAT6(Ab-641) Antibody  
Catalog Number: 21050  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P42226
    NCBI Protein: NP_003144.3
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around aa.639~643 (R-G-Y-V-P) derived from Human STAT6.
  • reactivity：  
  • Hu
  • appl_detail：  

  • Predicted MW: 110kd
    Western blotting: 1:500~1:1000
    Immunohistochemistry: 1:50~1:100

  • other_names：  
  • IL-4 Stat
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Specificity：  
  • The antibody detects endogenous level of total STAT6 protein.
  • Applications：  
  • WB IHC
  • Background：  

  • STAT6 is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor-associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. By screening an embryonic lung fibroblast cDNA library with a wildtype STAT6 probe, 2 variant cDNAs were identified, which were termed STAT6B and STAT6C, encoding an N-terminal 110-amino acid truncation and a 27-amino acid deletion in the SH2 domain, respectively. All the three variants are ubiquitously expressed with STAT6B expression greatest in spleen and STAT6C expression greatest in lung. STAT6B resembles an attenuated STAT6, but that STAT6C inhibits IL-4-mediated mitogenesis and cell surface antigen expression, and is not tyrosine phosphorylated

    Nelms K, et al. (1999) Annu Rev Immunol. 17:701-738.
    Malabarba M G, et al. (1996) Biochem. J. 319:865-872.
    Hou J, et al. (1994) Science. 265:1701-1706.
    Quelle F W, et al. (1995) Mol Cell Biol. 15: 3336-3343.
    Takeda K, et al. (1996) Nature. 380: 627-630.




 
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