Product Datasheet  
CD56(NCAM) Antibody  
Catalog Number: 21468  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P13591
    NCBI Protein: NP_000606.3
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
  • Immunogen：  
  • Peptide sequence around aa.850~854(Q-T-K-E-N)derived from Human CD56(NCAM).
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Predicted MW: 120-220kd
    Western blotting: 1:500~1:1000
  • other_names：  
  • MSK39; NCAM1;
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Specificity：  
  • The antibody detects endogenous levels of total NCAM protein.
  • Applications：  
  • WB
  • Background：  
  • NCAM (neural cell adhesion molecule, CD56) is an adhesion glycoprotein with five extracellular immunoglobulin-like domains followed by two fibronectin type III repeats. Structural diversity is introduced by alternative splicing resulting in different cytoplasmic domains (1). NCAM mediates neuronal attachment, neurite extension and cell-cell interactions through homo and heterophilic interactions. PSA (polysialic acid) post-translationally modifies NCAM and increases the metastatic potential of small cell lung carcinoma, Wilms+ tumor, neuroblastoma and rhabdomyosarcoma (2). CD56 and CD16 are commonly used to identify NK cells although some cells with the T cell markers CD3 and CD4 also express CD56 (3).

    Cunningham, B. A. et al. (1987) Science 236, 799-806.
    Seidenfaden, R. et al. (2003) Mol. Cell. Biol. 23, 5908-5918.
    Robertson, M.J. and Ritz, J. (1990) Blood 76, 2421-2438.



 
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