Product Datasheet  
Histone H4 (Acetyl-Lys5) Antibody  
Catalog Number: 12070  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: P62805;
    NCBI Gene#: 8359;
    NCBI Protein#: NP_003529.1
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Peptide sequence around acetylation site of Lysine 5(S-G-R(p)-G-K) derived from Human Histone H4.
  • reactivity：  
  • Hu Ms Rt Mk
  • appl_detail：  

  • Predicted MW: 11kd
    Western blotting: 1:500~1:1000

  • other_names：  
  • H4, H4/n, H4F2, H4FN, FO108
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic acetylpeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific acetylpeptide. Non-acetyl specific antibodies were removed by chromatogramphy using
  • Specificity：  
  • The antibody detects endogenous level of Histone H4 only when acetylated at Lysine 5.
  • Applications：  
  • WB
  • Background：  

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.




 
© Signalway Biotechnology All Rights Reserved.