Product Datasheet  
hnRNP C1/2 (Phospho-Ser260) Antibody  
Catalog Number: 12048  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: P07910;
    NCBI Gene#: 3183;
    NCBI Protein#: NP_001070910.1
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Peptide sequence around phosphorylation site of Serine 260 (D-D-S(p)-A-E) derived from Human hnRNP C1/2.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Predicted MW: 41kd
    Western blotting: 1:500~1:1000
  • other_names：  
  • C1, C2, HNRNP, HNRPC, SNRPC
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous level of hnRNP C1/2 only when phosphorylated at Serine 260.
  • Applications：  
  • WB
  • Background：  
  • Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules.



 
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