Product Datasheet  
BCL-2 (Phospho-Thr69) Antibody  
Catalog Number: 12036  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: P10415;
    NCBI Gene#: 596;
    NCBI Protein#: NP_000624.2
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Peptide sequence around phosphorylation site of Threonine 69 (A-R-T(p)-S-P) derived from Human BCL-2.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Predicted MW: 26kd
    Western blotting: 1:500~1:1000
  • other_names：  
  • PPP1R50, BCL2
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous level of BCL-2 only when phosphorylated at Threonine 69.
  • Applications：  
  • WB
  • Background：  
  • Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).



 
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