Product Datasheet  
IkappaB- beta (Phospho-Thr19) Antibody  
Catalog Number: 12011  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: Q15653;
    NCBI Gene#: 4793;
    NCBI Protein#: NP_001230045.1
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Peptide sequence around phosphorylation site of Threonine 19 (C-D-S(p)-G-L) derived from Human IkappaB- beta.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Predicted MW: 37kd
    Western blotting: 1:500~1:1000
  • other_names：  
  • IKBB, TRIP9
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous level of I kappaB- beta only when phosphorylated at Threonine 19.
  • Applications：  
  • WB
  • Background：  
  • Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.



 
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