Product Datasheet  
GRF-1 (Phospho-Tyr1105) Antibody  
Catalog Number: 12009  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: Q9NRY4;
    NCBI Gene#: 2909;
    NCBI Protein#: NP_004482.4
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Peptide sequence around phosphorylation site of Tyrosine 1105 (N-I-Y(p)-S-V) derived from Human GRF-1.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Predicted MW: 155kd
    Western blotting: 1:500~1:1000
  • other_names：  
  • GRLF1, P190A, P190-A, p190RhoGAP, p190ARhoGAP
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous level of GRF-1 only when phosphorylated at Tyrosine 1150.
  • Applications：  
  • WB
  • Background：  
  • Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'. May participate in the regulation of retinal development and degeneration. May transduce signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP). May also act as a tumor suppressor.



 
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