Product Datasheet  
Vitamin D Receptor (Phospho-Ser208) Antibody  
Catalog Number: 11994  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: P11473;
    NCBI Gene#: 7421;
    NCBI Protein#: NP_000367.1
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Peptide sequence around phosphorylation site of serine 208 (A-L-S(p)-P-V) derived from Human Vitamin D Receptor.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Western blotting: 1:500~1:1000
  • other_names：  
  • NR1I1; vitamin D receptor; vitamin D3 receptor;
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous level of Vitamin D Receptor only when phosphorylated at serine 208.
  • Applications：  
  • WB
  • Background：  

  • Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.

    Arriagada G, et al. (2007) J Steroid Biochem Mol Biol 103, 425-9. Jurutka PW, et al. (1996)Proc Natl Acad Sci U S A 93, 3519-24. Jurutka PW, et al. (1993)J Biol Chem 268, 6791-9.




 
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