Product Datasheet  
Adrenergic Receptor beta2 (Phospho-Ser346) Antibody  
Catalog Number: 11970  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: P07550;
    NCBI Gene#: 154;
    NCBI Protein#: NP_000015.1
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Peptide sequence around phosphorylation site of serine 346 (R-S-S(p)-L-K) derived from Human Adrenergic Receptor beta2.
  • reactivity：  
  • Hu
  • appl_detail：  

  • Western blotting: 1:500~1:1000

  • other_names：  
  • ADRB2R; B2AR; adrenergic receptor; beta-2;
  • Purification：  
  • Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • Specificity：  
  • The antibody detects endogenous level of Adrenergic Receptor beta2 only when phosphorylated at serine 346.
  • Applications：  
  • WB
  • Background：  

  • Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.

    Gao S, Malbon C, Wang HY (2014) J Mol Signal 9, 3
    24690384 Curated Info
    Vistein R, Puthenveedu MA (2013) Proc Natl Acad Sci U S A 110, 15289-94
    Gimenez LE, et al. (2012) J Biol Chem 287, 9028-40




 
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